From 2 movies with Clooney that I've seen recently.

From Men Who Stare At Goats:

Bob, have you ever heard of
"Optimum Trajectory"?
 
What?
 
"Optimum trajectory."
 
Your life is like a river.
 
And if you're aiming for a goal
that isn't your destiny,
 
…you'll always gonna be swimming
against the current.
 
Young Gandhi wants to be
a stock-car driver?
 
It's not gonna happen.
 
Little Anne Frank wants to
be a High School teacher.
 
Tough titty Anne.
That's not your destiny.
 
But you will go on to move
the hearts and minds of millions.
 
Find out what your destiny is
and the river will carry you.
 
Now, sometimes events in life…
 
…give an individual clues
as to where their destiny lies.

And from the movie Up In The Air:

"Make no mistake, we all die alone. Now those cult members in San Diego, with the sneakers and the Kool-Aid, they didn't die alone. I'm just saying there are options."